Human health being one, we have all, I think many of us either experienced ourselves or know someone who has experienced not feeling well in a space for various reasons, whether it's there's mold or there's poor air circulation, or it's too hot or too cold, even that. Is a simple example of feeling either better or worse because of your built environment. http://www.solvecast.com/articles/detail/15258-sustainable-design-resilience-planning-with-ariane-laxo